Abstract Number: 172

Acquired idiopathic anhidrosis: A review of cases seen in a tertiary dermatological centre

L.K. Tay , W.S. Chong

Meeting: 2013 Dermcoll

Session Information

Date: -

Session Title: Poster Presentations

Session Time: -

Introduction: Acquired idiopathic anhidrosis (AIA) is an
uncommon entity characterized by anhidrosis in the
absence of any neurological or sweat gland abnormalities.
Method: This is a retrospective review of cases seen during a 10-year period (Jan 2002-Oct 2011) in a tertiary dermatological centre. Inclusion criteria included all cases of generalised or partial anhidrosis confi rmed by provocative starch-iodine sweat test following an appropriate thermal stimulus, in the absence of any neurological or sweat gland dysfunction. Ectodermal dysplasias, poral dysfunction from chronic dermatoses, underlying neurological disorders with autonomic dysfunction, peripheral neuropathies and drug-induced causes were excluded.
Results: There were 15 Asian Chinese patients diagnosed with AIA, with a signifi cant male predominance and variable extent of body surface area involvement. These cases were mostly diagnosed at a relatively young age (mean 28.5 years), with mean disease duration of 13 months (range 1 month–10 years) prior to presentation. Most were healthy young individuals with no signifi cant past medical or drug history. Blood investigations (serum IgE, FBC, thyroid function test, ANA) were largely unremarkable. Anhidrotic areas demonstrated normal eccrine appendages with mild perivascular and peri-eccrine lymphocytic infi ltrate. No neurological abnormalities were detected clinically and on autonomic function test, sympathetic skin responses, nerve conduction tests, and appropriate neuroimaging studies.
Conclusion: AIA seems to be a heterogeneous group occurring with no major dysfunction other than anhidrosis, for which the pathogenesis remains unknown. Proper recognition and evaluation is paramount, especially for at-risk population, so that appropriate measures on the prevention of heat injuries can be instituted.