The Dermabond Prineo Skin Closure System (Ethicon US, LLC) is increasingly being used in place of skin staples or subcuticular sutures in elective orthopaedic surgical wound closure. It is reported to be as strong as some sutures, demonstrate greater skin holding strength than skin staples, provide an effective microbial barrier and minimise skin closure time. The Dermabond Prineo Skin Closure System combines a 2-octyl cyanoacrylate topical skin adhesive with a self-adhesive polyester mesh. Despite the widespread use of 2-octyl-cyanoacrylates as topical skin adhesives, only a relatively low rate of sensitization and allergic contact dermatitis has been reported. It is proposed that its rapid polymerisation protects itself from sensitization. We present a case series of allergic contact dermatitis to the Dermabond Prineo glue following orthopaedic surgery, confirmed with patch testing. We review the literature on allergic contact dermatitis to 2-octyl cyanoacrylate-containing topical skin adhesives and propose strategies for their safe use in surgery.