Abstract Number: 86

Avocado perseose, a biomimetic active ingredient forthe protection and accompaniment of infants’ skin

S. Brédif, J. Rocheteau, S. Leclère-Bienfait,C. de Belilovsky, C. Baudouin

Meeting: 2015 Dermcoll

Session Information

Date: -

Session Title: Poster Presentations

Session Time: -

Our investigations on infants’ skin, have provided some
evidence concerning its development, organization and biological
signature: barrier function in maturation, water handling
capacity in fluctuation, inflammation signals and
cellular resource to preserve. In order to accompany
infants’ skin development, we have developed an active
ingredient from avocado cake, according to optimised,
secured and eco-designed process, in compliance with our
sustainable policy. The patented natural ingredient,
avocado perseose (AP), is a rare 7-carbon sugars concentrate
whose molecular structure is in total affinity with the
skin. Indeed, among other sugars, only the avocado
perseose presented such range of activity and also a good
tolerance. First we have measured AP potential on water
barrier in keratinocytes and skin explants and we have
demonstrated that it stimulates ceramides production,
involucrine and transglutaminase proteins expression and
also hyaluronic acid synthesis. Then in models of LPS or
PMA-stressed keratinocytes, AP downregulated the release
of inflammatory mediators. Finally, in keratinocytes isolated
from babies and children skin samples, we have shown that
AP didn’t modulate gene expression profile of stem cells
markers whatever the marker in normal condition.
However, after UV irradiation, AP avoided the UV-induced
downregulation of the two main markers of interfollicular
stem cells: alpha6 and beta1 integrins. In conclusion,
avocado perseose acts as a biomimetic ingredient for a
perfect tolerance and a targeted efficacy into epidermis: it
reinforces the water skin barrier, fights against inflammatory
aggressions and preserves stem cells resource. So
avocado perseose constitutes a good response to the needs
of the infants’ skin.