The management of many metastatic malignancies has been revolutionised in recent years with the emergence of new biologics and reﬁnements in protocols. These agents include checkpoint inhibitors, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, EGFR mono- clonal antibody inhibitors, and rituximab amongst others.
These diverse agents have a range of toxicities that can impact signiﬁcantly on patients, sometimes precluding fur- ther treatment. Cutaneous toxicities are not uncommon and can impact signiﬁcantly on quality of life for these patients, sometimes requiring cessation of treatment. Der- matologists are increasingly required as part of the team managing these patients.
The oncological biologics relevant to dermatology will be brieﬂy discussed including their therapeutic indications, biology, cutaneous toxicities and dermatological manage- ment. A number of interesting cases will be presented and discussion of the complex management required in patients with multiple co-morbidities.
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