G. Wong1, E. Wee1, R. Kelly1
Granuloma annulare (GA) is an idiopathic skin disease that is generally asymptomatic but may can be disturbing to patients in terms of the appearance of the eruption. Generalised GA can prove difficult to treat, with numerous agents reported to be effective in case reports or small series.
Pentoxyfylline is a methyl-xanthine derivative that has been used in the treatment of various dermatological conditions. There are only limited reports in the literature regarding efficacy of pentoxifylline in GA.
We report 5 cases of GA (generalised, perforating and local variants) treated with oral pentoxifylline, with 4 showing dramatic response to treatment. These include patients who had previously trialled a number of therapies such as topical steroids, antimalarials, narrowband UVB and methotrexate with no improvement. Pentoxifyline is a low cost medication with a relatively good safety profile and should be considered as a first line systemic agent in the management of GA.