Abstract Number: 20

Prevalence of methicillin-resistant Staphylococcusaureus in children with atopic dermatitis, andcomparison to the general paediatric population: alongitudinal study

C. Chaptini, S. Quinn, G. Marshman

Meeting: 2015 Dermcoll

Session Information

Date: -

Session Title: Paediatric Dermatology Symposium

Session Time: -

Background: Given the increasing rate of methicillinresistant
Staphylococcus aureus(MRSA) skin infections in
the population, such infections might also be increasing in
patients with atopic dermatitis(AD). There are limited
studies on MRSA prevalence in the AD population, and no
previous studies in Australia.
Objectives: This study investigated the prevalence of
MRSA and MSSA in the paediatric AD population. It also
examined the rate of MRSA in children with AD, compared
to the general paediatric population, and investigated risk
factors for MRSA.
Methods: This is a longitudinal, retrospective study to
investigate, using logistic regression, the change of prevalence
of MRSA and MSSA in skin swabs of patients with AD,
aged 0–18 years, admitted to a large teaching hospital in
South Australia from 1999–2014(n = 289). Additionally, skin
and soft-tissue isolates positive for Staphylococcus
aureus, obtained from paediatric inpatients from 2010–
2014(n = 343), were analysed to investigate the proportion
of MRSA in patients with AD, compared to those without
AD.
Results: In total 78.5% of AD patients had MSSA and 7.0%
had MRSA. In each successive age period, the prevalence of
MRSA increased OR = 2.01(1.22–3.34), p = 0.007, so that
compared to 1999–2002, patients in 2011–2014 were
approximately 16 times more likely to have MRSA
(p = 0.012). There was an association between increasing
number of hospital admissions and MRSA, OR = 1.08(1.02,
1.14). MRSA rates are lower in those with AD compared to
those without AD, OR = 0.567(0.214–1.500), p = 0.253.
Conclusion: The prevalence of MRSA in AD is clearly on
the rise. This study provides reassurance for local practitioners
that most skin infections in children with AD are
methicillin-sensitive.