Redwan Al-Karim Bhuiyan
Adipose-derived stem cells (ADSC) are a potent skin regeneration agent. They release growth hormones and anti-inflammatory cytokines, promote tissue regeneration by boosting extracellular protein production, and secrete antioxidants that neutralize free radicals. The result obtained in an office technique, without cell incubation and counting, is stromal vascular fraction, which contains not only stem cells but also a variety of other active cells such as pericytes, preadipocytes, immune cells, and extracellular matrix. When adipose-derived stem cells were injected into the dermis, they enhanced skin density and attractiveness while also increasing skin hydration and the number of capillary capillaries. In this study our main goal is to describe the possibility of using autologous-derived medicines in face rejuvenation. A systematic review of English and non-English articles using MEDLINE and the Cochrane Controlled Trials Register (1960–2005), and EMBASE (1991–2005). Search terms included randomized controlled trial, controlled clinical trial, random allocation, double-blind method, experimental study, stem cell therapy, adipose tissue stem cell, skin aging, wound healing, fat cell. According to multiple studies it was found that most of the cases platelet rich plasma(PRP), ADSC are found safer and can be used for the therapy of skin defects and wounds. In addition, SVF is a source of stem cells, but its ability to regenerate is also dependent on other active cells. Regenerative medicine is still in its early stages. Physicians are fascinated by the mechanism of action of ADSCs and their multidirectional influence on dermal regeneration. ADSCs release antioxidative chemicals, stimulate wound healing, and secrete ECM proteins. Several studies have shown that ADSC injections enhance skin density and have anti-wrinkle benefits. Skin moisture increases, and the overall look improves. The majority of fat and stem cell transfers performed for cosmetic reasons are one-stage in-office procedures that do not include cytometry or cell counting. The survival and viability of stem cells appear to be substantially related to the harvesting procedure, and there are no unambiguous standards.